FZI Lung Research Core Facility

 

Welcome to the Lung Research Core Facility

The Lung Core Facility offers the opportunity to examine the function of the lungs.

For this purpose, it is possible to measure different lung function parameters under homeostasis or after inhalation provocation with the stressor methacholine in the mouse model using the Buxco Fine Point lung function system from DSI.

The system can be used, for example, to draw conclusions about airway resistance or dynamic compliance. Changes in these parameters are signs of pathological changes in the lungs, as they occur in chronic lung diseases such as asthma, COPD or pulmonary fibrosis.

The Lung Core Facility is headed by PD Dr. Sebastian Reuter, head of the Basic and Translational Lung Research working group. Through him, it is possible to carry out lung function measurements independently after familiarization with the equipment.

For work on the system, it is mandatory to submit a current animal experiment application with corresponding approval of the method, which is carried out invasively under anesthesia.

The Core Facility (PD Dr. Reuter) will be happy to assist with the formulation of appropriate passages.

PD Reuter has been active in experimental pneumological research since 2005 and is a proven specialist in murine lung disease models and translational research into diseases of the respiratory system. To this end, Priv. Doz. Dr. Reuter has developed various innovative experimental murine in vitro/in vivo and human in vitro models that are suitable for investigating immunological processes that contribute to the development and progression of lung disease, as well as for analyzing new therapeutic approaches.

By combining purely murine models, the humanized mouse model, human in vitro models and the characterization of human primary material, it has not only been possible to identify numerous mechanisms of action in recent years, but also to characterize new therapeutic approaches and investigate their potential efficacy in these translational approaches “in humans”.


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